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- A Fungal Fight for Sight: Mycotic Sinusitis and Optic Nerve Compression
A Fungal Fight for Sight: Mycotic Sinusitis and Optic Nerve Compression
Veterinary Ophthalmology, 2025
Obi Veterinary Education
November 12, 2025
Holz, J. L., Spiess, B. M., Pot, S. A.
Background
Mycotic sphenopalatine sinusitis is a rare but severe condition that can lead to optic nerve compression and vision loss. This study describes a case series of affected animals, focusing on clinical presentation, diagnostic imaging, and treatment outcomes.
Methods
The study examined multiple cases of mycotic sphenopalatine sinusitis with optic nerve involvement. Diagnostic approaches included advanced imaging (CT/MRI) and fungal culture. Treatment strategies, including antifungal therapy and surgical intervention, were evaluated for efficacy.
Results
Affected animals exhibited progressive visual deficits linked to fungal invasion and compression of the optic nerves. Imaging revealed sinus opacification and nerve impingement. Treatment with systemic antifungals and, in some cases, surgical debridement led to varying degrees of visual improvement and resolution of infection.
Limitations
The study acknowledges a small sample size and variability in treatment response. Additionally, long-term follow-up was limited, making it difficult to assess recurrence rates.
Conclusions
Early diagnosis and aggressive treatment of mycotic sphenopalatine sinusitis are crucial to preserving vision. Imaging plays a key role in assessing disease extent and guiding therapy. Further research is needed to optimize treatment protocols and long-term outcomes.
(A) T2 TSE sagittal MRI: Rostral part with heterogeneous T2 hypointense tissue, caudal part with homogeneous T2 hyperintense material representing fluid accumulation; (B) gross pathology: Mass lesion in situ (white arrows), rostral part with granulation tissue and peripheral ossification, caudal part with pus-like surface coatings; (C) gross pathology: The optic nerve (black arrows) overlying the lesion appears flattened; (D) gross pathology: Rostral part of the lesion in detail.
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