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- Attenuation Correction in 18F-Sodium Fluoride PET of Equine Foot and Fetlock
Attenuation Correction in 18F-Sodium Fluoride PET of Equine Foot and Fetlock
VRU 63(6): 771-778
Standardized uptake values and attenuation correction in 18F-sodium fluoride PET of the equine foot and fetlock
Background: The article is a study published in Veterinary Radiology & Ultrasound that discusses the use of standardized uptake values (SUVmax) and attenuation correction in 18F-sodium fluoride PET of the equine foot and fetlock.
Study: The study aimed to provide reference values for 18F-NaF SUVmax in the equine distal extremity and assess the effect of attenuation correction.
Method: The study used a retrospective secondary analysis design and analyzed 18F-NaF PET/CT data of equine distal limbs acquired at the UC Davis Veterinary Medical Teaching Hospital between August 2016 and October 2019.
Results: The study found that attenuation correction significantly affected the 18F-NaF SUVmax in horses, with the effect varying depending on the anatomical site. Significant differences in SUVmax were observed between different anatomical regions, with the highest SUVmax observed in the distal phalanx.
Conclusions: The study concludes that attenuation correction is necessary for accurate quantitative measurement of 18F-NaF uptake in bone and recommends CT-based attenuation correction if CT data are available. However, as the effect on attenuation correction remains limited to less than a doubling of the signal intensity in the largest part of the foot, nonattenuation corrected images of the distal limb likely remain relevant for subjective clinical interpretation.
Sagittal 18F-NaF PET images of the foot of a 15-year-old quarter horse mare. Nonattenuation corrected (NAC) image (A) and CT-based attenuation corrected (CTAC) image (B) of the foot are presented, displayed with the same parameters (WL 15, WW 30). The CTAC image is brighter than the NAC image. The difference in brightness between the two images is most noticeable at the navicular bone (arrows). These images also demonstrate how the dorsal aspect of the distal phalanx (arrowhead) has the highest SUV and the central part of the proximal phalanx (asterisk) the lowest. (PET: 740 MBq 18F-NaF 1 hour prior to imaging, 10 min acquisition, 0.8 mm thick, 22 cm FOV, 300 × 300 matrix)
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