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- Contrast-Enhanced Ultrasound in Dogs: Differentiating Neoplastic and Non-Neoplastic Urinary Bladder Lesions
Contrast-Enhanced Ultrasound in Dogs: Differentiating Neoplastic and Non-Neoplastic Urinary Bladder Lesions
VRU 63(5): 609-619
Carlotta Spediacci, Martina Manfredi, Giulia Sala, Tiziana Liuti, Nicolas Israeliantz, Davide Danilo Zani, Mauro Di Giancamillo, Maurizio Longo
Background: Contrast-enhanced ultrasound (CEUS) can provide quantitative information on enhancement patterns and perfusion of lesions. No published studies have compared CEUS parameters in neoplastic and non-neoplastic urinary bladder lesions in dogs.
Study: The aim of this prospective, pilot study was to quantitatively characterize the CEUS pattern of neoplastic and non-neoplastic urinary bladder lesions in dogs.
Method: Fourteen dogs with cyto-histopathological diagnoses were included (seven malignant and seven inflammatory lesions). B-mode ultrasound was performed followed by CEUS examination after an intravenous bolus injection of 0.04 mL/kg of contrast medium, and TICs were elaborated by dedicated software.
Results: Neoplastic lesions had subjectively shorter rise time (RT), time to peak (TTP) and fall time (FT) than inflammatory lesions. Based on ROC curve analyses, fall time ≥ 10.49 s was the most reliable parameter for diagnosing non-neoplastic disease in this small sample of dogs.
Conclusions: The results of this pilot study suggest that neoplastic and non-neoplastic diseases may present different TICs. A FT higher than 10.49 s may be the only reliable cut-off to help characterizing neoplastic and non-neoplastic lesions of the urinary bladder in dogs, although this result must be interpreted with caution.
Contrast-enhanced ultrasound images obtained with a multi-frequency (10-19 MHz) microconvex electronic array probe with a mechanical index of 0.3 from a dog with a neoplastic urinary bladder lesion. A: Long axis standard B-mode sonogram of the urinary bladder showing a large inhomogeneous and poorly marginated mass occupying most of the lumen with multifocal hypoechoic areas (*). B: Long axis contrast-enhanced ultrasound (CEUS) sonogram of the urinary bladder of the same lesion showing marked and heterogeneous enhancement
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