Did you know that periventricular glial tumor could have a worse outcome post RT?

Canine presumed glial brain tumours treated with radiotherapy: Is there an inferior outcome in tumours contacting the subventricular zone?

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Carla Rohrer Bley, Chris Staudinger, Tim Bley, Laura Marconato, Silvia Sabattini, Katrin Beckmann

Background
Canine glial brain tumors treated with radiotherapy display variable survival outcomes, ranging from 2 to 28 months. In humans, glioblastomas contacting the subventricular zone (SVZ) have a higher propensity for recurrence and shortened survival. This study aimed to determine whether canine glial tumors in contact with the SVZ have an inferior prognosis compared to non-contacting tumors.

Methods
A retrospective cohort study was conducted involving 32 dogs with presumed primary glial brain tumors treated with radiotherapy. Tumors were classified as contacting the SVZ (SVZ+) or not (SVZ−) based on MRI findings. Treatment involved varying radiation protocols (10 × 4 Gy, 10 × 4 Gy with boost, and 20 × 2.5 Gy). Survival outcomes, including time to progression (TTP), overall survival (OS), and tumor-specific survival (TSS), were analyzed using Kaplan-Meier and Cox regression methods.

Results
-Median TTP for all cases was 534 days, significantly shorter for SVZ+ tumors (260 days) compared to SVZ− tumors (687 days).

-SVZ+ tumors had a higher progression rate (94.1% vs. 40%) and CNS metastasis (52.9% vs. 13.3%)
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-Median TSS was 609 days overall, but shorter for SVZ+ tumors (306 days) than SVZ− tumors (719 days).

-Ventricular invasion correlated with worse outcomes, including shorter TTP and OS.

Background
Canine glial brain tumors treated with radiotherapy display variable survival outcomes, ranging from 2 to 28 months. In humans, glioblastomas contacting the subventricular zone (SVZ) have a higher propensity for recurrence and shortened survival. This study aimed to determine whether canine glial tumors in contact with the SVZ have an inferior prognosis compared to non-contacting tumors.

Methods
A retrospective cohort study was conducted involving 32 dogs with presumed primary glial brain tumors treated with radiotherapy. Tumors were classified as contacting the SVZ (SVZ+) or not (SVZ−) based on MRI findings. Treatment involved varying radiation protocols (10 × 4 Gy, 10 × 4 Gy with boost, and 20 × 2.5 Gy). Survival outcomes, including time to progression (TTP), overall survival (OS), and tumor-specific survival (TSS), were analyzed using Kaplan-Meier and Cox regression methods.

Results
-Median TTP for all cases was 534 days, significantly shorter for SVZ+ tumors (260 days) compared to SVZ− tumors (687 days).

-SVZ+ tumors had a higher progression rate (94.1% vs. 40%) and CNS metastasis (52.9% vs. 13.3%)
.
-Median TSS was 609 days overall, but shorter for SVZ+ tumors (306 days) than SVZ− tumors (719 days).

-Ventricular invasion correlated with worse outcomes, including shorter TTP and OS.

Limitations
Lack of histopathological confirmation limited tumor type and grade specificity.
The retrospective design led to variability in imaging protocols and follow-up.
Some factors (e.g., SVZ contact, ventricular contact, and invasion) overlapped, complicating analysis.
Lack of histopathological confirmation limited tumor type and grade specificity.
The retrospective design led to variability in imaging protocols and follow-up.
Some factors (e.g., SVZ contact, ventricular contact, and invasion) overlapped, complicating analysis.

Conclusions
Tumors contacting the SVZ in dogs are associated with a shorter time to progression, tumor-specific survival, and higher rates of CNS metastasis. Despite achieving local tumor control with radiotherapy, these findings highlight the need for new strategies addressing metastatic patterns in canine glial tumors.

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