Does iodinated contrast media inhibit bacterial growth?

Iodinated non-ionic contrast medium does not inhibit Escherichia coli growth in ex vivo inoculated canine urine

Derré, M. G., Steinbach, S. M., Hendrix, G. K., Stanton, M., & Adams, L. G.

Study: The study aimed to investigate the effect of iohexol on standardized quantitative urine culture results in dogs. The authors hypothesized that the presence of iohexol in inoculated urine samples would result in lower bacterial concentrations and decrease culture sensitivity.

Methods: An experimental controlled study was conducted using urine samples collected from a single client-owned dog. The urine sample was divided into aliquots and inoculated with Escherichia coli. Different volumes of contrast or saline were added to the aliquots and quantitative culture results were compared. Two different incubation times between the preparation of aliquots and culture were evaluated.

Results: All aliquots from samples inoculated with E. coli had the same reported quantitative result. Iohexol did not show any anti-E. coli properties in canine urine cultures for dilutions up to 1:2 contrast:urine and concentrations up to 120 mgI/mL. No difference was reported when iohexol was incubated with inoculated urine for 15 minutes or 24 hours.

Conclusions: Based on the experimental conditions described, administration of iohexol before the collection of urine during urologic procedures does not negatively impact the isolation and growth of E. coli.

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