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Jesika El Rifiova, Frederike Schiborra, Peter-John Mäntylä Noble, Nina Vigevani, Richard J. Blundell, James Guillem
Background
This case report describes the computed tomography (CT) findings in a dog with Ménétrier-like disease (MLD), a rare form of chronic giant hypertrophic gastritis. The condition is characterized by gastric mucosal hypertrophy and the formation of rugal folds, resembling the cerebriform appearance reported in human Ménétrier’s disease. The study highlights the utility of CT imaging and histopathology in diagnosing this condition, which has not been previously documented in veterinary literature.
Methods
A 9-year-old male Boston Terrier presented with hyporexia, weight loss, and a history of chronic esophageal reflux. Imaging studies included abdominal ultrasonography and a full-body CT scan. Gastroscopy was performed, and multiple biopsy samples were obtained from the gastric wall for histopathological evaluation.
Results
CT findings included pronounced thickening of the rugal folds in the gastric fundus and body, creating a cerebriform pattern. The mucosa showed enhancement in the arterial and portal venous phases and contained cystic structures. Ultrasonography corroborated these findings, revealing hyperechoic mucosa with cystic formations. Histopathology confirmed foveolar hyperplasia, cystic dilation of glands, and minimal inflammation, consistent with MLD. Medical treatment was initiated, but the condition progressed, leading to euthanasia due to respiratory complications.
Limitations
This single-case report is limited by the lack of postmortem examination, which could have clarified systemic associations or co-morbidities. The absence of standardized therapeutic protocols for MLD in dogs also highlights a gap in veterinary knowledge.
Conclusions
This study establishes CT imaging as a critical tool for diagnosing MLD in dogs, providing detailed visualization of gastric hypertrophy and associated changes. The findings suggest that MLD should be included in the differential diagnoses for gastric diseases with similar imaging features. Histopathology remains essential for definitive diagnosis.
Dorsal soft tissue algorithm postcontrast CT image of the cranial abdomen during the arterial (A) and portal postcontrast phase (B)
of the dog. Hyperplasia of the rugal folds is visible occupying most of the gastric lumen. Multiple small, round, nonenhancing cystic structures are
present within the mucosa (white arrows). Sagittal (C) and transverse (D) soft tissue algorithms showing maximum intensity projection images of
the stomach (soft tissue reconstruction, arterial postcontrast phase) show a cerebriform structure within the lumen
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