Escherichia coli-associated follicular cystitis in dogs: Clinical and pathologic characterization

Sanna J. Viitanen, Laura Tuomisto, Nina Salonen, Katariina Eskola, Kristel Kegler

Study: The study aimed to characterize clinical and pathologic features of follicular cystitis in dogs and to explore the possible role of Escherichia coli as an associated cause.

Methods: The study was a retrospective descriptive study that identified dogs diagnosed with follicular cystitis from medical records. Paraffin embedded bladder wall biopsies were subject to in situ hybridization for E. coli 16SrRNA identification.

Results: Follicular cystitis was diagnosed in large breed female dogs with a history of chronic recurrent urinary tract infections. Positive E. coli 16SrRNA signal was detected within developing, immature and mature TLSs in 7/8 dogs, through submucosal stroma in 8/8 dogs and within the urothelium in 3/8 dogs. The ultrasonographic appearance of follicular bladder wall lesions was clearly visible in 2/8 dogs.

Conclusions: Chronic inflammation associated with an intramural E. coli infection in the urinary bladder wall represents a possible triggering factor for the development of follicular cystitis.

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