Wow did not know they went there......

Journal of comparative pathology 2024

Transmissible venereal tumour with encephalic metastasis in dogs

Erick P.F. Souto,Daniel R. Rissi, et al.

Background
Transmissible venereal tumour (TVT) is a contagious neoplasm in dogs, typically transmitted through mating or other social interactions. While usually localized to the genital area, TVT can occasionally metastasize to other organs, including the central nervous system (CNS). This study aimed to describe the epidemiological, clinical, pathological, and immunohistochemical characteristics of encephalic metastases of TVT in six dogs over 23 years.

Methods
The study reviewed records from 6,218 canine submissions to the Laboratory of Animal Pathology at the Federal University of Campina Grande, Brazil, from 2000 to 2023. Cases of TVT with CNS metastases were identified via histological and immunohistochemical analysis, focusing on markers such as vimentin, CD45RA, and lysozyme.

Results
Six cases (0.09% of total submissions) of TVT with encephalic metastases were identified among 99 TVT cases. Affected dogs, aged 2 to 12 years, exhibited neurological signs like lethargy, seizures, and ataxia. Metastases were primarily subdural and extraparenchymal, located in the telencephalon and brain base. Histologically, tumors displayed round-cell morphology, with immunolabelling for vimentin and CD45RA confirming their histiocytic origin. Metastatic TVTs caused significant neuroparenchymal compression.

Limitations
The study was limited by its small sample size (six cases) and a single geographic location. Additionally, the variability in immunohistochemical markers, such as lysozyme and Iba1, posed challenges for consistent diagnostic confirmation.

Conclusions
Encephalic metastases of TVT, though rare, should be considered in the differential diagnosis of neurological diseases in endemic regions. Immunohistochemistry remains a key tool for diagnosis, with markers such as vimentin and CD45RA being particularly valuable. The study highlights the importance of recognizing the potential for CNS involvement in TVT cases.

Metastatic transmissible venereal tumours, brain, dogs. (A) Case 5. Yellow, multilobulated mass effaces left frontal lobe. (B) Case 5. Multilobulated, well-demarcated, extraparenchymal white mass effaces left frontal lobe and compresses surrounding neuroparenchyma. (C) Case 4. Well-demarcated, extraparenchymal white to tan mass effaces left telencephalic hemisphere and compresses surrounding neuroparenchyma. (D) Case 4. Well-demarcated, extraparenchymal white mass effaces left temporal lobe and compresses surrounding neuroparenchyma. (E). Case 6. Well-demarcated, extraparenchymal white mass effaces hypothalamus and optic chiasm. (F) Case 3. Well-demarcated white mass effaces left thalamus and compresses surrounding neuroparenchyma and left lateral ventricle.

How did we do?

Login or Subscribe to participate in polls.

Disclaimer: The summary generated in this email was created by an AI large language model. Therefore errors may occur. Reading the article is the best way to understand the scholarly work. The figure presented here remains the property of the publisher or author and subject to the applicable copyright agreement. It is reproduced here as an educational work. If you have any questions or concerns about the work presented here, reply to this email.